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Milk thistle granules 250g

Milk thistle granules 250g

Regular price 13,00 €
Regular price Sale price 13,00 €
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Silymarin in its most original form, a dietary supplement to help the liver and the whole organism

Maticnjak Bestsellers, Naslovna, Plant extracts, Preporučeni proizvodi za dijabetes, Preporučeni proizvodi za imunitet, Sikavica, The most wanted,


100% raw granulate of peeled milk thistle seeds (Silybum marianum)


One teaspoon (5g) 2 times a day, alone or in a glass of water, juice, smoothie, yogurt or porridge.

Method of storage and notes

A dietary supplement is not a substitute or substitute for a balanced diet and a healthy lifestyle. People taking medication should consult a doctor before taking it.

Not recommended for pregnant women, nursing mothers and children.

Store in a dark and dry place up to 25°C.

Delivery to HR and EU

Delivery 1-3 working days

Delivery price: €3.98

Free delivery within the Republic of Croatia for orders over €40

Delivery abroad:

- Germany €8 / 3-4 days
- Austria €8 / 3-4 days
- Slovenia €5 / 1-2 days
- Sweden €10 / 4-6 days
- Belgium €10 / 4-5 days
- Czech Republic €8 / 3-4 days
- Denmark €10 / 5-6 days
- France €10 / 5-6 days
- Greece €16 / 6-7 days
- Ireland €10 / 5-6 days
- Italy €10 / 4-5 days
- Hungary €8 / 1-2 days
- Netherlands 10€ /
4-5 days
- Poland €10 / 3-4 days
- Slovakia €8 / 3-4 days
- Spain €10 / 5-6 days

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Milk thistle granulate is a completely natural product from the seeds (fruit) of milk thistle from domestic organic cultivation, with as much as 140 mg of silymarin in 10 grams of milk thistle granulate.

The power of milk thistle granules is in the complete silymarin complex, and it is known to help efficiently restore damaged hepatocytes and keep them healthy for a long time.

Silymarin is even 10 times stronger antioxidant than vitamin E. In addition to protecting the body's cells from oxidative shock, silymarin increases by 35% the level of another important antioxidant - glutathione, which is responsible for cleaning the liver of toxins, which enables the liver to clean the blood, activates dopamine receptors and forms the basis of the healthy production of serotonin - the hormone of happiness .

  • natural source of vitamin E (400mg/kg)
  • high content of unsaturated fatty acids
  • protects, nourishes and strengthens the liver
  • supports the proper functioning of the metabolism
  • maintains a normal level of cholesterol in the blood

With pure mechanical processing, we preserved all the nutrients of this fantastic plant, and with just two teaspoons a day, you have a completely natural source of the highest quality silymarin.

It does not contain allergens, additives, preservatives and artificial colors. Made with 100% love, 0% chemistry .


Silymarin: the active ingredient of sycamore that helps repair damaged liver cells from alcohol and other toxic substances, stimulating protein synthesis. It has been proven that it restores liver cells (hepatoprotective effect) and stimulates their growth and protects the liver from harmful side effects of medical drugs. Silymarin binds dangerous chemicals, alcohol and heavy metals and removes them from the body.

In addition to protecting the body's cells from oxidative shock, silymarin increases glutathione levels (an important compound for improving liver function and cleansing it of toxins) in the liver for even 35% , whose antioxidant effect contributes to liver health.

Glutathione levels drop if we are exposed to high levels of toxins on a daily basis. Activates dopamine receptors and forms the basis of healthy serotonin production - hormone of happiness .

What science says

  • Milk thistle contains a group of plant substances known as the silymarin complex and is known to have antioxidant, anti-inflammatory and antiviral effects (1,2,3).
  • It is regularly used as a complementary therapy by people who have liver damage due to conditions such as alcoholic liver disease, non-alcoholic fatty liver disease, hepatitis (4,5,6). It can also help liver damage caused by more serious diseases (7,8,9,10).
  • Sikavica can be useful as a complementary therapy in patients with type 2 diabetes (11). It was recently confirmed that people who routinely took sikavica experienced significant reductions in fasting blood sugar and HbA1c (12).
  • Due to its antioxidant and strong anti-inflammatory effect, sikavica can be a useful dietary supplement for people with acne. A study showed that people who took silymarin every day for 8 weeks reduced the number of acne lesions by as much as 53% (13).
  • Sikavica promotes bone mineralization and prevents loss of bone tissue (14,15). Researchers suggest that it may be a useful therapy to prevent bone loss in menopausal women (16,17).
  • Sikavica can help prevent age-related decline in brain function (18,19).
  1. Kim MS, Ong M, Qu X. Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination? World J Gastroenterol. 2016 Jan 7;22(1):8-23. doi: 10.3748/wjg.v22.i1.8. PMID: 26755857; PMCID: PMC4698510.
  2. Aller R, Izaola O, Gómez S, Tafur C, González G, Berroa E, Mora N, González JM, de Luis DA. Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study. Eur Rev Med Pharmacol Sci. 2015 Aug;19(16):3118-24. PMID: 26367736.
  3. Ferenci P, Dragosics B, Dittrich H, Frank H, Benda L, Lochs H, Meryn S, Base W, Schneider B. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol. 1989 Jul;9(1):105-13. doi: 10.1016/0168-8278(89)90083-4. PMID: 2671116.
  4. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010 Oct;24(10):1423-32. doi: 10.1002/ptr.3207. PMID: 20564545.
  5. Losser MR, Payen D. Mechanisms of liver damage. Semin Liver Dis. 1996 Nov;16(4):357-67. doi: 10.1055/s-2007-1007249. PMID: 9027949.
  6. Federico A, Dallio M, Loguercio C. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules. 2017 Jan 24;22(2):191. doi: 10.3390/molecules22020191. PMID: 28125040; PMCID: PMC6155865.
  7. Polachi N, Bai G, Li T, Chu Y, Wang X, Li S, Gu N, Wu J, Li W, Zhang Y, Zhou S, Sun H, Liu C. Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer - A comprehensive review. Eur J Med Chem. 2016 Nov 10;123:577-595. doi: 10.1016/j.ejmech.2016.07.070. Epub 2016 Jul 29. PMID: 27517806.
  8. Vue B, Chen QH. The Potential of Flavonolignans in Prostate Cancer Management. Curr Med Chem. 2016;23(34):3925-3950. doi: 10.2174/0929867323666160823151833. PMID: 27557939.
  9. Imai-Sumida M, Chiyomaru T, Majid S, Saini S, Nip H, Dahiya R, Tanaka Y, Yamamura S. Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways. Oncotarget. 2017 Sep 8;8(54):92032-92042. doi: 10.18632/oncotarget.20734. PMID: 29190895; PMCID: PMC5696161.
  10. Bosch-Barrera J, Menendez JA. Silibinin and STAT3: A natural way of targeting transcription factors for cancer therapy. Cancer Treat Rev. 2015 Jun;41(6):540-6. doi: 10.1016/j.ctrv.2015.04.008. Epub 2015 Apr 27. PMID: 25944486.
  11. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. The therapeutic potential of milk thistle in diabetes. Rev Diabetes Stud. 2014 Summer;11(2):167-74. doi: 10.1900/RDS.2014.11.167. Epub 2014 Aug 10. PMID: 25396404; PMCID: PMC4310066.
  12. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Diabetes Res. 2016;2016:5147468. doi: 10.1155/2016/5147468. Epub 2016 Jun 1. PMID: 27340676; PMCID: PMC4908257.
  13. Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne Ahmed Salih Sahib, Haidar Hamid Al-Anbari, Mohammed Salih and Fatima Abdullah; Journal of Clinical & Experimental Dermatology Research; Sahib et al., J Clin Exp Dermatol Res 2012, 3:5 DOI: 10.4172/2155-9554.1000163
  14. Kim JL, Kim YH, Kang MK, Gong JH, Han SJ, Kang YH. Antiosteoclastic activity of milk thistle extract after ovariectomy to suppress estrogen deficiency-induced osteoporosis. Biomed Res Int. 2013;2013:919374. doi: 10.1155/2013/919374. Epub 2013 May 28. PMID: 23781510; PMCID: PMC3678416.
  15. El-Shitany NA, Hegazy S, El-Desoky K. Evidence for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine. 2010 Feb;17(2):116-25. doi: 10.1016/j.phymed.2009.05.012. Epub 2009 Jul 3. PMID: 19577454.
  16. Mohd Fozi NF, Mazlan M, Shuid AN, Isa Naina M. Milk thistle: a future potential anti-osteoporotic and fracture healing agent. Curr Drug Targets. 2013 Dec;14(14):1659-66. doi: 10.2174/13894501113146660222. PMID: 24093748.
  17. Abdul Jalil MA, Shuid AN, Muhammad N. Osteoporotic fracture healing: potential use of medicinal plants from the tropics. Curr Drug Targets. 2013 Dec;14(14):1651-8. doi: 10.2174/1389450114666131217113759. PMID: 24354586.
  18. Karimi G, Vahabzadeh M, Lari P, Rashedinia M, Moshiri M. "Silymarin", a promising pharmacological agent for the treatment of diseases. Iran J Basic Med Sci. 2011 Jul;14(4):308-17. PMID: 23492971; PMCID: PMC3586829.
  19. Borah A, Paul R, Choudhury S, Choudhury A, Bhuyan B, Das Talukdar A, Dutta Choudhury M, Mohanakumar KP. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. CNS Neurosci Ther. 2013 Nov;19(11):847-53. doi: 10.1111/cns.12175. Epub 2013 Oct 14. PMID: 24118806; PMCID: PMC6493565

Questions and answers

Find the most frequently asked questions and answers on the blog - MILK THISTLE Q & A

Milk thistle in discount packages

Sikavica granulate is an indispensable part of Matičnjak dedicated product packages recommended by phytotherapist Iva Bačlija :

  • HEALTHY LIVER package for the protection of the key organ for the proper functioning of the body with sikavica, black cumin and hemp
  • DETOX package with three preparations that make an excellent cure for thorough cleaning
  • ANTI-PARASITE package with products that will make life miserable and destroy the lives of pests, while restoring your health and energy
  • SLIM package it provides a sufficient amount of energy and nutrients that will keep you full, while providing enough calories and nutrients

100% love, 0% chemistry

Maticnjak domestic production of 100% natural products and plant extracts. Experience the power of nature in its original form!

For all questions regarding Matičnjak product and its use, please feel free to contact us on 099 532 6688, and all related questions Ops Biotics+ skin care lines on 099 8004 726.

Can't find your medicinal herb? - Ask a phytotherapist .


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Based on 82 reviews
Oleg Sanković

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Granulat sikavica pakiranje

Bilo bi lijepo da za kontinuiranu uporabu imate veća pakiranja i bolju cijenu kada je pakiranje veće. Supruga i ja koristimo stalno i ovo nam je malo skupo a 250 gr nestane za tren. Konkurencija ima bolje cijene i za sada kupujemo ipak kod vas zbog vjere u kvalitetu. Želja mi je da bude dostupnije cjenovno da mogu i dalje kupovati kao i nešto niži iznos kupovine za besplatnu dostavu.

Boni Cebalo

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Aleksandra Jovanic-Sinko
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Odličan je, lako se konzumira i kombinuje sa jogurtom ili sokovima.

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Odličan proizvod, transaminaze padaju :)

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