Macerate of sweet wormwood 200ml and Piskavica Plus 250g

Macerate of sweet wormwood in black cumin oil (Macerat 14) is your ideal ally in the fight against viruses, bacteria and fungi and the regulation of immunity in a natural way, and Fenugreek Plus is the richest natural source of iron and an ideal supplement to sweet wormwood.

The action of Macerat 14 is based on the synergy of medicinal herbs and cold-pressed oil. Sweet wormwood is immersed (macerated) in black cumin oil for a period of six weeks, which "binds" its medicinal properties.

Fenugreek Plus is a nutritional supplement based on medicinal plants and the best plant source of iron with as much as 33 mg in 100 g of product.

4 complementary herbs have been added to fenugreek, which makes this mixture a complete phytotherapeutic preparation:

• fenugreek seeds (eng. fenugreek ) is also called "Greek seed" because, according to folklore, the ancient Greeks used it for strength before fighting. Today, it is mostly used in cooking.
• sikavica
• dried skin of black grapes
• turmeric
• oat seeds - a good source of selenium, beta glucan and indigestible fiber
  
  

What science says about sweet wormwood and black cumin

Black cumin

A plant that ancient peoples say " heals everything except death ".

• The premise of the research is that black cumin increases the activity and number of T-lymphocytes and NK cells that form natural ones defense mechanism against viruses, bacteria and fungi (1,2,3,4,5,6).

• With its multiple nutritional and phytochemical compounds, black cumin oil becomes one of the better ingredients to balance and support innate and acquired immune function (7,8,9).
  

Find references to scientific works on the effect of black cumin in the " References " tab.

Sweet Pelin

It is traditionally used in Chinese medicine for various purposes.

• This medicinal plant is best known for treating malaria (10), but it is also used to reduce fever and swelling (10). However, recent studies also point to the potential of artemisinin and related compounds from sweet wormwood, commonly called artemisinins, in the fight against viral infections, inflammation and certain types of mutated cells and formations (11).

• Initial studies point to positive effects of artemisinin in the fight against SARS-CoV-2 infection or symptoms associated with COVID-19 and WHO-supervised clinical studies on the potential of artemisinin in the fight against COVID-19 are currently ongoing (11).

References

1. Khalife R., Hodroj MH, Fakhoury R., Rizk S. Thymoquinone from nigella sativa seeds promotes the antitumor activity of noncytotoxic doses of topotecan in human colorectal cancer cells in vitro. Planta Medica.

2. Majeed A., Muhammad Z., Ahmad H., Hayat SSS, Inayat N., Siyyar S. Nigella sativa L.: uses in traditional and contemporary medicines–An overview. Acta Ecol. Son. in 2020

3. Goyal SN, Prajapati CP, Gore PR, Patil CR, Mahajan UB, Sharma C., Talla SP, Ojha SK Therapeutic potential and pharmaceutical development of thymoquinone: a multitargeted molecule of natural origin. Front. Pharmacol. 2017;8:656.

4. Ahmad A., Mishra RK, Vyawahare A., Kumar A., ​​Rehman MU, Qamar W., Khan AQ, Khan R. Thymoquinone (2-Isoprpyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/ anticancer agent: chemistry and biological effects. Saudi Pharm. J. 2019

5. Hossen MJ, Yang WS, Kim D., Aravinthan A., Kim J.-.H., Cho JY Thymoquinone: an IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities. Sci. Tail. 2017;7:1–12.

6. Aziz N., Son Y.-.J., Cho JY Thymoquinone suppresses IRF-3-mediated expression of type I interferons via suppression of TBK1. Int. J. Mol. Sci. 2018;19:1355.

7. Glick M. "Could This Millennia-Old Remedy Become a Pharmaceutical Marvel?" Discover Magazine. Published online June 17, 2021.

8. Shen HH et al. "Cold-pressed Nigella sativa oil standardized to 3% thymoquinone potentiates omega-3 protection against obesity-induced oxidative stress, inflammation, and markers of insulin resistance accompanied with conversion of white to beige fat in mice." Antioxidants (Basel), vol. 9, no. 6 (June 4, 2020): 489

9. Mukherjee M et al. "Autoimmune responses in severe asthma." Allergy, Asthma, & Immunology Research, vol. 10, no. 5 (September 2018): 428-447

10. Skyles AJ, Sweet BV. Alternative therapies. Wormwood. Am J Health Syst.Pharm. 2004;61:239-42.

11. Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Karim Farmanpour-Kalalagh, Arman Beyraghdar Kashkooli, Alireza Babaei, Ali Rezaei and Alexander R. van der Krol

What science says about fenugreek

• Fenugreek seeds It has been used in herbal and Chinese medicine for thousands of years, most often as tonic for metabolism and general health , and supporting digestion (1). Affects on diabetes type 1 and 2 with an increase in general carbohydrate tolerance, even in individuals without metabolic conditions such as diabetes (2, 3, 4). Also, it is the best natural substance for lymph detoxification , and has a vital role in irrigating cells with nutrients and removing toxic waste (5)

• Sikavica - can be useful as a complementary therapy in patients with type 2 diabetes (6). It was recently confirmed that people who routinely took sikavica experienced significant reductions in fasting blood sugar and HbA1c (7).

• Sow oats - they are rich in fiber, and it is known that fiber is extremely important for the health of the digestive system

• Turmeric - a spice and one of the most effective food supplements. Curcumin is the main active substance and has been widely researched, so it has been proven to be extremely effective strong antioxidant activity (8)

References

1. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003 Feb;8(1):20-7. PMID: 12611558.

2. Kochhar A, Nagi M. Effect of supplementation of traditional medicinal plants on blood glucose in non-insulin-dependent diabetics: a pilot study. J Med Food. 2005 Winter;8(4):545-9. doi: 10.1089/jmf.2005.8.545. PMID: 16379570

3. Madar Z, Abel R, Samish S, Arad J. Glucose-lowering effect of fenugreek in non-insulin dependent diabetics. Eur J Clin Nutr. 1988 Jan;42(1):51-4. PMID: 3286242.

4. Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J. 2014;13:7. Published 2014 Jan 18. doi:10.1186/1475-2891-13-7

5. Fenugreek: A review on its nutraceutical properties and utilization in various food products

6. Kazazis CE, Evangelopoulos AA, Kollas A, Vallianou NG. The therapeutic potential of milk thistle in diabetes. Rev Diabetes Stud. 2014 Summer;11(2):167-74. doi: 10.1900/RDS.2014.11.167. Epub 2014 Aug 10. PMID: 25396404; PMCID: PMC4310066.

7. Voroneanu L, Nistor I, Dumea R, Apetrii M, Covic A. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Diabetes Res. 2016;2016:5147468. doi: 10.1155/2016/5147468. Epub 2016 Jun 1. PMID: 27340676; PMCID: PMC4908257.

8. Menon VP, Sudheer AR. Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol. 2007;595:105-25. doi: 10.1007/978-0-387-46401-5_3. PMID: 17569207.