Macerate 01 in black cumin oil 200ml

Macerate 01 is an oil preparation in which fennel, basil, nettle, chokeberry and ginger are steeped in black cumin oil.

Black cumin seeds and the oil obtained from them by cold pressing regulate immunity - the research suggests that black cumin increases the activity of T-lymphocytes and NK cells, which create a natural defense mechanism against viruses, bacteria and fungi.

By taking two teaspoons a day, you get the best of this carefully selected herb. 

For six weeks, the plants are immersed in cold-pressed black cumin oil , which "binds" to itself, that is, macerates their healing properties. Black cumin oil combines the effects of these five medicinal plants in the best way, because it is the only oil that, by cold pressing, releases essential oil, such as thymoquinone , which has an immunomodulatory and anti-inflammatory effect. 

What science says

Various studies have investigated the interesting actions of black cumin seeds and we have highlighted the following:

Protects against allergic reactions and regulates asthma – according to studies, the thymoquinone molecule supports lung function by dilating the bronchi and relieving asthma symptoms (1, 2, 3, 4, 5)

Regulate sugar and cholesterol levels - research shows that black cumin oil increases the secretion of insulin from the beta-cell of the pancreas, while thymoquinone lowers bad cholesterol and blood glucose levels (6, 7, 8, 9)

Promote healthy skin, hair and nails – researchers state that this effect is achieved by the fact that black cumin provides the body with an abundance of unsaturated fatty acids and antioxidants (10)

They regulate immunity - the conclusion of the research is that black cumin increases the activity of T-lymphocytes and NK cells, which create a natural defense mechanism against viruses, bacteria and fungi (11,12,13,14,15).

Relieve the symptoms of gastritis and stomach infections thanks to their strong immunomodulatory effect (16)

A study conducted by Mukherjee et al. In 2005, it was shown that basil leaf essential oil can improve cellular and humoral immunity. Cellular immunity does not involve the production of antibodies, while antibodies are produced in the case of humoral immunity. Basil leaves can help strengthen the immune system by creating antibodies and releasing mediators (17.)Basil leaves can help control stress. Basil leaves can have good rejuvenating activity that can help the body to relax and reduce stress. It can also help improve memory. Basil leaves can control stress due to its antihypoxic effect - the ability to reduce stress due to oxidation in the body (17). 

With a history of more than 2000 years, nettle has been used as a natural medicine for centuries (18). It is believed that toxins in the body system cause chronic inflammation, such as skin and arthritic disorders, and that nettle, with its alkalinity, neutralizes acids and excretes toxins through urine (19). Nettle has a purifying astringent effect on blood and skin diseases (19). As a diuretic, nettle can help quickly eliminate toxins neutralized in the body (19). It can improve the efficiency of absorption of nutrients and guarantee the smooth running of digestive processes, preventing the accumulation of toxic toxins (20). It also stimulates the lymphatic system, which supports the kidneys in removing toxins from the body (20). 

Aronia is an abundant source of phenolic compounds, including procyanidins, anthocyanins, phenolic acids and their analogues (21,22). All of these are powerful bioactive antioxidants (21,22) that play a role in maintaining health. 

1 Ikhsan M., Hiedayati N., Maeyama K., Nurwidya F. Nigella sativa as an anti-inflammatory agent in asthma. BMC Research Notes. 2018;11(1, article no. 744)

2) Saadat S., Mohammadi M., Fallahi M., keyhanmanesh R., Aslani MR Protective effect of α-hederin, an active ingredient of Nigella sativa, on tracheal response and pneumonia in guinea pigs sensitive to ovalbumin. Journal of Physiological Sciences. 2015;653):285–292. doi: 10.1007/s12576-015-0367-6.

3) Salem AM, Bamosa AO, Qutub HO, et al. Effect of Nigella sativa supplementation on lung function and inflammatory mediators in partially controlled asthma: a randomized controlled trial. Annals of Saudi Medicine. 2017;37(1):64–71. doi: 10.5144/0256-4947.2017.64.

4) Koshak A., Wei L., Koshak E., et al. Nigella sativa supplementation improves asthma control and biomarkers: a randomized, double-blind, placebo-controlled trial. Phytotherapy research. 2017;31(3):403–409. doi: 10.1002/ptr.5761.

5) Boskabady MH, Farhadi J. Possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests in chemical warfare victims: a randomized, double-blind, placebo-controlled trial. Journal of alternative and complementary medicine. 2008;14(9):1137–1144. doi: 10.1089/acm.2008.0049.

6) Kaatabi H., Bamosa AO, Lebda FM, Al ELq AH, Al-Sultan Beneficial effect of Nigella sativa seeds on lipid profile in patients with type 2 diabetes2. Journal of Family and Community Medicine. 2012;19(3):155–160. 

7) Omidi H., Khorram S., Mesgari M., Asghari-Jafarabadi M., Tarighat-Esfanjani A. Effects of separate and simultaneous supplementation of nano-sized clinoptilolite and Nigella sativa on oxidative stress, antioxidant parameters and body weight in type 2 diabetic rats. Biomedicine and pharmacotherapy. 2017;96:1335-1340. 10.1016/j.biopha.2017.11.077.

8) Daryabeygi-Khotbehsara R., Golzarand M., Ghaffari MP, Djafarian K. Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: a systematic review and meta-analysis. Complementary therapies in medicine. 2017;35:6–13.

9) Kaatabi H., Bamosa AO, Badar A.,​​​​​​​et al. >Nigella sativa improves glycemic control and alleviates oxidative stress in patients with type 2 diabetes: a placebo-controlled clinical trial with blinded participants. 2015;


10)NIGELLA SATIVA SEED, A NEW BEAUTY CARE INGREDIENT: A REVIEW SP Sudhir *1, VO Deshmukh 2 and HN Verma1 Department of Natural Sciences 1, Jaipur National University, Jaipur, Rajasthan, India. Sarkone Life Sciences 2, Dubai, UAE


11) Majeed A., Muhammad Z., Ahmad H., Hayat SSS, Inayat N., Siyyar S. Nigella sativa L.: use in traditional and modern medicine – A review. Acta Ecol. Sin. in 2020


12) Goyal SN, Prajapati CP, Gore PR, Patil CR, Mahajan UB, Sharma C., Talla SP, Ojha SK Therapeutic potential and pharmaceutical development of thymoquinone: a multitarget molecule of natural origin. In front. Pharmacol. 2017; 8: 656.

13) Ahmad A., Mishra RK, Vyawahare A., Kumar A., Rehman MU, Qamar W., Khan AQ, Khan R. Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone) as a chemopreventive / anticancer agent: chemistry and biological effects. Saudi Pharm. J. 2019.

14) Hossen MJ, Yang WS, Kim D., Aravinthan A., Kim J.-.H., Cho JY Thymoquinone: an IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activity. Sci. Tail. 2017;7:1–12.

15) Aziz N., Son Y.-.J., Cho JY Thymoquinone suppresses IRF-3-mediated type I interferon expression via suppression of TBK1. Int. J. Mol. Sci. 2018;19:1355.

16) Salem EM et al. Comparative study of Nigella sativa and triple therapy in the eradication of Helicobacter pylori. Saudi Journal of Gastroenterology 2010;16:207-14.

17)Al-Maskari MY, Hanif MA, Al-Maskri AY, Al-Adawi S. Basil: A natural source of antioxidants and nutraceuticals. natural Products and Their Active Compounds on Disease Prevention 2012 Aug (pp. 463-471). Nova Science Publishers, Inc. Available from: https://squ.pure.elsevier.com/en/publications/basil-a-natural-source-of-antioxidants-and-neutraceuticals 

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21)Sidor A., Drożdżyńska A., Gramza-Michalowska A. Black chokeberry (Aronia melanocarpa) and its products as potential health-promoting factors–an overview. Trends Food Sci. Technol. 2019;89:45–60. doi: 10.1016/j.tifs.2019.05.006. [CrossRef] [Google Scholar] [Ref list]

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+Information and statements are for educational purposes and should not replace your doctor's advice.